Docteur Catherine de Waele, Md PhD

Recherche fondamentale ORL
Recherche fondamentale ORL

• Ancien interne des hôpitaux de Paris.

• Directeur de recherche CNRS.

• Titres académiques : thèse en Médecine et thèse en Neurosciences.

Les travaux fondamentaux sont basées sur la recherche des mécanismes moléculaires impliqués dans la récupération fonctionnelle après lésion. Nous travaillons sur quatre modèles :

 

La surdité et les acouphènes.

 

La compensation vestibulaire après labyrinthectomie unilatérale qui induit des déficits statiques et dynamiques posturaux (troubles de l’équilibre) et oculo-moteurs (diminution du gain du réflexe vestibulo-oculaire) et perceptuels (vertiges, déviation de la perception de la verticale subjective).

 

La paralysie faciale et la régénérescence axonale après lésion périphérique du nerf facial.

 

L'équilibre, la marche et le système vestibulaire.

Recherche fondamentale ORL
Recherche fondamentale ORL

Principales publications

Chiarovano E, Vidal PP, Magnani C, Lamas G, Curthoys IS, de Waele C. 2016
Absence of Rotation Perception during Warm Water Caloric Irrigation in Some Seniors with Postural Instability.
Front Neurol.   Jan 25;7:4. doi: 10.3389/fneur.2016.00004. eCollection. Free PMC Article

Barrois R, Oudre L, Moreau T, Truong Ch, Vayatis N, Buffat S, Yelnik A, de Waele C, Gregory T, Laporte S, Vidal PP, Ricard D. 2015
Quantify osteoarthritis gait at the doctor's office: a simple pelvis accelerometer based method independent from footwear and aging.
Comput Methods Biomech Biomed Engin.;18 Suppl 1:1880-1. doi: 10.1080/10255842.2015.1072414. Epub 2015 Aug 28.


Chiarovano E, de Waele C, MacDougall HG, Rogers SJ, Burgess AM and Curthoys IS 2015
Maintaining balance when looking at a virtual reality three-dimensional display of a field of moving dots or at a virtual reality scene. Front. Neurol. 6:164. doi: 10.3389/fneur.2015.00164

Chiarovano E, Darlington C, Vidal PP, Lamas G, de Waele C. 2014
The role of cervical and ocular vestibular evoked myogenic potentials in the assessment of patients with vestibular schwannomas.
PLoS One. Aug 19;9(8):e105026. doi: 10.1371

Makoukji J, Belle M, Meffre D, Stassart R, Grenier J, Shackleford G, Fledrich R, Fonte C, Branchu J, Goulard M, de Waele C, Charbonnier F, Sereda MW, Baulieu EE, Schumacher M, Bernard S, Massaad C. 2012
Lithium enhances remyelination of peripheral nerves.
Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3973-8. doi: 10.1073/pnas.1121367109. Epub  Feb 21.

Chioravano E, Zamith F, Vidal PP, de Waele C Ocular and cervical VEMPs: a study of 74 patients suffering from peripheral vestibular disorders 2011
Clinical Neurophysiology Clin Neurophysiol. 2011 Aug;122(8):1650-9. doi: 10.1016/j.clinph..01.006. Epub 2011 Feb 8.

de Waele C, Smith PF, Wang G, Zhang M, Darlington CL 2010
The effects of the Chinese herbal medicine EMF01 on salicylate-induced tinnitus in rats. Zheng Y, Vagal S, Zhu XX,.J Ethnopharmacol. Mar 24;128(2):545-8.
 

Vidal PP, Mbongo F, Huy PT, de Waele C. 2009
From animal research to the bed side: detection of unilateral vestibular lesions in patients complaining of unsteadiness. J Vestib Res. Jan;19(5-6):147-57.
 

Beraneck M, Uno A, Vassias I, Idoux E, de Waele C, Vidal PP, Vibert N. Evidence against a role of gap junctions in vestibular compensation. Neurosci Lett. 2009 Jan 30;450(2):97-101.
Role of vestibular input in triggering and modulating postural responses in unilateral and bilateral vestibular loss patients. Mbongo F, Qu'hen C, Vidal PP, Tran Ba Huy P, de Waele C. Audiol Neurootol. 2009;14(2):130-8. Epub 2008 Oct 14.

Argence M, Vassias I, Kerhuel L, Vidal PP, de Waele C. 2008
Stimulation by cochlear implant in unilaterally deaf rats reverses the decrease of inhibitory transmission in the inferior colliculus. Eur J Neurosci. Oct;28(8):1589-602
 

Szatanik M, Vibert N, Vassias I, Guénet JL, Eugène D, de Waele C, Jaubert J.
Behavioral effects of a deletion in Kcnn2, the gene encoding the SK2 subunit of small-conductance Ca2+-activated K+ channels. Neurogenetics. 2008 Oct;9(4):237-48. Epub 2008 Jul 5.PMID: 18604572
 

Mbongo F, Tran Ba Huy P, Vidal PP, de Waele C.
Relationship between dynamic balance and self-reported handicap in patients who have unilateral peripheral vestibular loss. Otol Neurotol. 2007 Oct;28(7):905-10.
 

Mbongo F, Qu'hen C, Vidal PP, Tran Ba Huy P, de Waele C. 2008
Role of vestibular input in triggering and modulating postural responses in unilateral and bilateral vestibular loss patients. Audiol Neurootol. 2009;14(2):130-8. Epub  Oct 14.

Eleore L, Ardehali MR, Vassias I, Vidal PP, de Waele C. 2007
Amino acid transporter (VIAAT, VGLUT2) and chloride cotransporter (KCC1, KCC2 and NKCC1) expression in the vestibular nuclei of intact and labyrinthectomized rat. Exp Brain Res. Oct;182(4):449-58. National Institutes of Health

Miyamoto T, Fukushima K, Takada T, de Waele C, Vidal PP. 2007
Saccular stimulation of the human cortex: a functional magnetic resonance imaging study. Neurosci Lett. Aug 9;423(1):68-72

Dumas G, de Waele C, Hamann KF, Cohen B, Negrevergne M, Ulmer E, Schmerber S. [Skull vibration induced nystagmus test] 2007
Ann Otolaryngol Chir Cervicofac. Sep;124(4):173-83.